2 Inhibitory aftereffect of Ned-19 (100?M) on NAADP-induced signalling in permeabilized cells. their relative importance for NAADP-induced Ca2+ discharge from two-photon permeabilized pancreatic acinar cells. In these cells, cholecystokinin-elicited Ca2+ discharge is normally mediated by NAADP. TPC2-KO decreased NAADP-induced Ca2+ discharge by 64%, however the mix of TPC2-KO and an […]