Insets show nTg mice with no hTDP-43 expression and nuclear h+mTDP-43 expression. vulnerable forebrain regions, corticospinal tract degeneration, and motor spasticity recapitulating key aspects of FTLD and primary lateral sclerosis. Only rare cytoplasmic phosphorylated and ubiquitinated TDP-43 inclusions were seen in hTDP-43-NLS mice, suggesting that cytoplasmic inclusions were not required […]
Daily Archives: May 24, 2023
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